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Genetic amniocentesis following multifetal pregnancy reduction does not increase the risk of pregnancy loss
Author(s) -
McLean Lynn K.,
Evans Mark I.,
Carpenter, Jr Robert J.,
Johnson Mark P.,
Goldberg James D.
Publication year - 1998
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199802)18:2<186::aid-pd232>3.0.co;2-i
Subject(s) - amniocentesis , pregnancy , obstetrics , medicine , gynecology , advanced maternal age , retrospective cohort study , prenatal diagnosis , biology , fetus , genetics
A collaborative, retrospective study of patients who had undergone multifetal pregnancy reduction (MFPR) to twins and subsequent genetic amniocentesis was performed to determine if amniocentesis increased the risk of pregnancy loss. Seventy‐nine patients from three centres underwent MFPR and subsequent amniocentesis. The pregnancy loss rate was 5·06 per cent in this group. In comparison, the loss rate from a control collaborative series of patients who underwent MFPR only was 11·19 per cent, which was not statistically different. Thus, it appears that amniocentesis following MFPR is unlikely to increase the pregnancy loss rate. © 1998 John Wiley & Sons, Ltd.