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Chorion villus sampling and limb deficiency—cause or coincidence?
Author(s) -
Firth Helen
Publication year - 1997
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199712)17:13<1313::aid-pd298>3.0.co;2-6
Subject(s) - medicine , lower limb , gestation , pregnancy , hypoplasia , upper limb , prenatal diagnosis , obstetrics , anatomy , surgery , fetus , biology , genetics
Chorion villus sampling (CVS) is a widely used technique in first trimester prenatal diagnosis. In the early 1990s, two clusters of babies with limb defects following CVS were reported, raising the possibility of a causal association between early CVS and transverse limb deficiency. The evidence for this association is reviewed and shows a diminishing risk for transverse limb deficiency with advancing gestation. The risk of limb deficiency extends through the period of limb morphogenesis and slightly beyond; falling from levels 10–20‐fold above background at nine weeks and below, to levels approaching (or only a few‐fold above) background at 11 weeks and beyond. © 1997 by John Wiley & Sons, Ltd.