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Maternal serum alpha‐fetoprotein and human chorionic gonadotropin in pregnant women with acute parvovirus B19 infection with and without fetal complications
Author(s) -
Komischke Klemens,
Searle Karen,
Enders Gisela
Publication year - 1997
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199711)17:11<1039::aid-pd191>3.0.co;2-u
Subject(s) - medicine , human chorionic gonadotropin , fetus , alpha fetoprotein , pregnancy , gonadotropin , obstetrics , parvovirus , gynecology , parvoviridae , hormone , biology , immunology , virus , hepatocellular carcinoma , genetics
Maternal serum alpha‐fetoprotein (MS‐AFP) and human gonadotropin (MS‐hCG) were retrospectively determined in 137 sera from 65 pregnant women with an acute parvovirus B19 infection. In 35 of the pregnant women, fetal complications occurred (group 1); in the remaining 30 women, there were no fetal complications (group 2). In group 1, significant elevations of MS‐AFP were detected in 13 of the 35 women (37 per cent) and of MS‐hCG in 25 of the 35 women (71 per cent). In nine of those women, sera were obtained before occurrence of fetal complications and MS‐AFP was elevated in one case and MS‐hCG in four cases. In one woman, both MS‐AFP and MS‐hCG were elevated. In group 2, significant elevations of MS‐AFP were found in two of the 30 women (6·7 per cent) and of MS‐hCG in five of the 30 women (16·7 per cent). Neither MS‐AFP nor MS‐hCG appears to be a regular early marker for poor pregnancy outcome in parvovirus B19‐infected pregnancies, although they were frequently elevated at the time of complications. © 1997 John Wiley & Sons, Ltd.