Premium
PRENATAL DETECTION OF Hb MUTATIONS USING TRANSCERVICAL CELLS
Author(s) -
ADINOLFI M.,
ELHASHEMITE N.,
SHERLOCK J.,
WARD R. H. T.,
PETROU M.,
RODECK C.
Publication year - 1997
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199706)17:6<539::aid-pd106>3.0.co;2-8
Subject(s) - prenatal diagnosis , medicine , obstetrics , mutation , pregnancy , genetics , fetus , biology , gene
Prenatal diagnoses were performed on six selected pairs of parents known to be carriers of Hb mutations by testing transcervical cells (TCCs) retrieved, prior to chorionic villus sampling (CVS), by aspiration of the cervical mucus from the pregnant mothers at 10–12 weeks of gestation. A concordance between the results of testing chorionic villus cells and isolated clumps of trophoblastic cellular elements was observed in four of the six cases. © 1997 John Wiley & Sons, Ltd.