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MATERNAL SERUM ALPHA‐FETOPROTEIN AND EPITHELIAL TUMOUR MARKER CONCENTRATIONS ARE NOT INCREASED BY FETAL SACROCOCCYGEAL TERATOMA
Author(s) -
KIRKINEN P.,
HEIN S.,
VANAMO K.,
RYYNäNEN M.
Publication year - 1997
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199701)17:1<47::aid-pd19>3.0.co;2-i
Subject(s) - trisomy , fetus , medicine , alpha fetoprotein , aneuploidy , down syndrome , endocrinology , prenatal diagnosis , andrology , pregnancy , biology , chromosome , biochemistry , genetics , psychiatry , hepatocellular carcinoma , gene
Maternal serum alpha‐fetoprotein (AFP) and total beta‐human chorionic gonadotrophin (hCG) concentrations were measured at the 15th gestational week in ten pregnancies complicated by fetal sacrococcygeal teratoma. The findings corresponded to those in normal pregnancies. Similarly, third‐trimester concentrations of cancer antigen 12‐5, tumour‐associated trypsin inhibitor, and the amino‐terminal propeptide of type III procollagen in the maternal serum were not significantly elevated. Histologically mature and immature/malignant cases did not differ from each other as regards the above‐mentioned parameters. This abnormality cannot be detected by maternal serum trisomy screening in the second trimester. © 1997 by John Wiley & Sons, Ltd.