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PRENATAL DIAGNOSIS OF SUPERNUMERARY der(22)t(11;22) ASSOCIATED WITH THE DANDY‐WALKER MALFORMATION IN A FETUS
Author(s) -
CHEN CHIHPING,
LIU FENFEN,
JAN SHEAUWEN,
YANG YUHCHENG,
LAN CHUNGCHI
Publication year - 1996
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199612)16:12<1137::aid-pd979>3.0.co;2-k
Subject(s) - medicine , prenatal diagnosis , karyotype , supernumerary , trisomy , dandy–walker syndrome , fetus , obstetrics , anatomy , pregnancy , chromosome , biology , surgery , genetics , hydrocephalus , gene
We present the first report of prenatally diagnosed Dandy‐Walker malformation with the karyotype of partial trisomy 11 and 22 due to familial translocation t(11;22)(q23;q11) inherited in three generations. We demonstrate that the Dandy‐Walker malformation can be an associated congenital malformation of supernumerary der(22)t(11;22) syndrome and emphasize the importance of chromosomal analysis and genetic counselling in the obstetric management of prenatally diagnosed Dandy‐Walker malformation.