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MATERNAL SERUM SCREENING AND TRISOMY 16 CONFINED TO THE PLACENTA
Author(s) -
GROLI CATERINA,
CERRI VALERIA,
TARANTINI MICHELE,
BELLOTTI DANIELA,
JACOBELLO CARMELO,
GIANELLO RENZO,
ZANINI ROBERTO,
LANCETTI SARA,
ZAGLIO SILVANO
Publication year - 1996
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199608)16:8<685::aid-pd907>3.0.co;2-2
Subject(s) - amniocentesis , chorionic villus sampling , trisomy , obstetrics , chorionic villi , medicine , aneuploidy , placenta , gynecology , down syndrome , prenatal diagnosis , pregnancy , fetus , human chorionic gonadotropin , biology , genetics , chromosome , psychiatry , gene
Five cases of trisomy 16 confined to the placenta have been detected by invasive procedures (amniocentesis and chorionic villus sampling) after high‐risk results for Down syndrome and neural tube defects in a maternal serum screening programme of 6614 consecutive cases. All five pregnancies displayed unusually elevated levels of human chorionic gonadotropin and four out of five also had raised alpha‐fetoprotein values. No structural malformation was present but all five pregnancies were complicated by fetal growth retardation, and one by intrauterine death. From our results, we suggest that both amniocentesis and chorionic villus sampling should be considered in the management of cases with high mid‐trimester levels of these analytes.