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Lowering of tumoral interstitial fluid pressure by prostaglandin E 1 is paralleled by an increased uptake of 51 Cr‐EDTA
Author(s) -
Rubin Kristofer,
Sjöquist Mats,
Gustafsson AnnMarie,
Isaksson Britta,
Salvessen Gerd,
Reed Rolf K.
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000601)86:5<636::aid-ijc6>3.0.co;2-r
Subject(s) - microdialysis , interstitial fluid , prostaglandin , adjuvant , prostaglandin e , stroma , chemistry , medicine , extracellular fluid , endocrinology , pathology , cancer research , extracellular , biochemistry , immunohistochemistry
High intra‐tumoral fluid pressure (TP IF ) may impair uptake of anticancer drugs into tumors, contributing to poor efficiency in treatment of carcinomas. Here, we demonstrate that lowering of TP IF parallels increased transport of 51 Cr‐EDTA (m.w. 341) into tumor interstitium. Introduction of 15 μg prostaglandin E 1 (PGE 1 ) ‐methyl ester into the s.c. tissue surrounding transplanted rat colonic (PROb) carcinomas or chemically‐induced rat mammary carcinomas, lowered TP IF by 30%. Transcapillary transport into the interstitium of PROb tumors quantified by microdialysis increased by 39.6% after PGE 1 treatment 40 min prior to administration of 51 Cr‐EDTA (n=6; p <0.05) compared to vehicle (n=10). In mammary tumors, PGE 1 increased transport into the tumors by 86.9% over controls (n=16; p <0.05). Both tumors had well developed stroma containing collagen and hyaluronan. Our data demonstrate that adjuvant treatment with PGE 1 lowers TP IF , and enhances transport into the tumors. This principle may be of value as adjuvant therapy in treatment of solid malignancies with currently used anticancer drugs. Int. J. Cancer 86:636–643, 2000. © 2000 Wiley‐Liss, Inc.