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Comparison of lifestyle and risk factors among Japanese with and without gastric cancer family history
Author(s) -
Huang XinEn,
Tajima Kazuo,
Hamajima Nobuyuki,
Xiang Jin,
Inoue Manami,
Hirose Kaoru,
Tominaga Suketami,
Takezaki Toshiro,
Kuroishi Tesuo,
Tokudome Shinkan
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000501)86:3<421::aid-ijc18>3.0.co;2-z
Subject(s) - family history , medicine , odds ratio , epidemiology , cancer , multivariate analysis , smoking history , demography , case control study , sociology
To find specific risk factors of gastric cancer (GC) independent of GC family history (GCFH), 2 studies were conducted using the database of the Hospital‐based Epidemiological Research Program at Aichi Cancer Center: (i) a comparison of lifestyles between non‐cancer cases with positive and negative GCFH status and (ii) a case‐reference investigation of subjects with and without GCFH, treated separately. The first showed no significant variation of GCFH status with regard to smoking, drinking and most food habits. Multivariate analyses in the case‐referent studies revealed odds ratios (ORs) for GC associated with habitual smoking of 2.78 (95% CI 1.22–6.28) for those with and 2.74 (95% CI 1.76–4.26) for those without GCFH. In individuals with GCFH, an independently lowered OR (0.52, 95% CI 0.27–0.99) was evident for frequent consumption of raw vegetables, whereas the opposite was noted for pickled vegetables (2.39, 95% CI 1.28–4.45). No statistically significant interaction was found between GCFH and selected lifestyle items. In conclusion, our results suggest a limited influence of GCFH on risk factors for GC. Int. J. Cancer 86:421–424, 2000. © 2000 Wiley‐Liss, Inc.