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Genistein attenuates peritoneal metastasis of azoxymethane‐induced intestinal adenocarcinomas in Wistar rats
Author(s) -
Iishi Hiroyasu,
Tatsuta Masaharu,
Baba Miyako,
Yano Hiroyuki,
Sakai Noriko,
Akedo Hitoshi
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000501)86:3<416::aid-ijc17>3.0.co;2-#
Subject(s) - azoxymethane , genistein , medicine , metastasis , adenocarcinoma , cancer research , cancer , carcinogenesis
The effects of the soybean isoflavonoid genistein on the development of bombesin‐enhanced peritoneal metastasis from intestinal adenocarcinomas induced by azoxymethane (AOM) were investigated in male inbred Wistar rats. From the beginning of the experiment, rats were given 10 weekly s.c. injections of AOM (7.4 mg/kg body weight) and s.c. injections of bombesin (40 μg/kg body weight) every other day, and from week 16, s.c. injections of genistein (5 or 10 mg/kg body weight) every other day until the end of the experiment in week 45. Bombesin significantly increased the incidence of intestinal tumors and of cancer metastasis to the peritoneum. Although genistein administered at either dose had little or no effect on the enhancement of intestinal carcinogenesis by bombesin or on the location, histologic type, depth of involvement, labeling index, or growth pattern of intestinal cancers, it significantly decreased the incidence of cancer metastasis. Genistein also significantly decreased the incidence of lymphatic vessel invasion of adenocarcinomas, which was enhanced by bombesin. Our findings indicate that genistein attenuates cancer metastasis by inhibiting cancer cell invasion into lymphatic vessels through activities that do not affect the growth of intestinal cancers. Int. J. Cancer 86:416–420, 2000. © 2000 Wiley‐Liss, Inc.