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Mammalian cell transformation and aneuploidy induced by five bisphenols
Author(s) -
Tsutsui Takeki,
Tamura Yukiko,
Suzuki Ayako,
Hirose Yutaka,
Kobayashi Morio,
Nishimura Hiroyuki,
Metzler Manfred,
Barrett J. Carl
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000415)86:2<151::aid-ijc1>3.0.co;2-0
Subject(s) - xenoestrogen , aneuploidy , biology , hamster , transformation (genetics) , genetics , locus (genetics) , microbiology and biotechnology , gene , cancer , estrogen receptor , breast cancer , chromosome
Bisphenol‐A (BP‐A), a monomer of plastics used in numerous consumer products and a xenoestrogen, induces cellular transformation and aneuploidy in Syrian hamster embryo (SHE) cells. In this study, the abilities of 4 other bisphenols to induce cellular transformation and genetic effects in SHE cells were examined and compared to BP‐A. Cellular growth was inhibited by all bisphenols in a concentration‐related manner. The growth inhibitory effect of the bisphenols ranked: BP‐5 > BP‐4 > BP‐3 > BP‐2 or BP‐A. Morphological transformation of SHE cells was induced by BP‐A, BP‐3, BP‐4 and BP‐5, and the induced‐transformation frequencies were highest with BP‐4. None of the bisphenols induced gene mutations at the Na + /K + ATPase locus or the hprt locus, or chromosomal aberrations in SHE cells. By contrast, aneuploidy induction in the near‐diploid range was exhibited by BP‐A, BP‐3, BP‐4 or BP‐5, corresponding to the transforming activity of each compound. The results indicate that BP‐A, BP‐3, BP‐4 and BP‐5 exhibit transforming activity in SHE cells, while BP‐2 does not, and that aneuploidy induction may be a causal mechanism of the transforming activity. Int. J. Cancer 86:151–154, 2000. © 2000 Wiley‐Liss, Inc.