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Association of inverted sinonasal papilloma with non‐sinonasal head‐and‐neck carcinoma
Author(s) -
Dictor Michael,
Johnson Anna
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000315)85:6<811::aid-ijc13>3.0.co;2-3
Subject(s) - medicine , paranasal sinuses , papilloma , carcinoma , incidence (geometry) , inverted papilloma , larynx , cohort , epidemiology , retrospective cohort study , cancer , cohort study , head and neck cancer , dermatology , oncology , pathology , surgery , physics , optics
The nature and pathogenesis of inverted papilloma of the nose and paranasal sinuses are debated. Evidence suggesting a viral association is controversial, and epidemiological evidence has pointed to tobacco smoking as a potential etiologic factor. A retrospective regional cohort of 197 patients with sinonasal papilloma was compared with a cohort of 1583 patients with nasal polyps showing a similar distribution by age and sex. All instances of head‐and‐neck carcinoma diagnosed in both cohorts during a 38‐year calendar period were culled from the regional cancer registry, the incidence rate ratio was computed (papilloma:polyp, on tumors detected at the time of or prior to the index diagnosis), and the clinical details were obtained. Nine instances of oral or laryngeal squamous‐cell carcinoma, all in men, were identified in the papilloma cohort, and 7 labial, oral or laryngeal carcinomas (2 in women) in patients with polyps. In addition, 5% of the papillomas progressed to sinonasal carcinoma, including 2 cases among those with other primary head‐and‐neck carcinomas. The incidence‐rate ratio for non‐sinonasal head‐and‐neck carcinoma was 12.8 (95% CI, 3.7 to 50; p < 0.0001). Among the papilloma patients with oral/laryngeal carcinoma, 8 smoked tobacco. Inverted sinonasal papilloma is associated with an increase in non‐sinonasal head‐and‐neck carcinoma, and tobacco may be a causative link. Int. J. Cancer 85:811–814, 2000. © 2000 Wiley‐Liss, Inc.