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L‐myc polymorphism in cancer patients, healthy blood donors and elderly, tumor‐free individuals in Russia
Author(s) -
Togo Alexandr V.,
Suspitsin Evgeny N.,
Grigoriev Maxim Yu.,
Ilyushik Eduard S.,
Karpova Maria B.,
Hanson Kaido P.,
Imyanitov Evgeny N.
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000315)85:6<747::aid-ijc1>3.0.co;2-v
Subject(s) - genotype , allele , medicine , breast cancer , lung cancer , gastroenterology , colorectal cancer , cohort , cancer , oncology , biology , genetics , gene
L‐myc polymorphism was investigated in 95 breast cancer (BC), 63 colorectal cancer (CC) and 58 lung cancer (LC) patients, as well as in 122 healthy, middle‐aged blood donors (HBDs) and 184 elderly, tumor‐free individuals. The occurrence of the S allele in the BC cohort (57%) was significantly higher than that in middle‐aged, healthy females (41%) and elderly, non‐affected women (47%), implying involvement of the L‐myc genotype in BC susceptibility (age‐adjusted OR = 1.74, 95% CI 1.11–2.73, p = 0.016). L‐myc allele distribution in CC and LC was similar to that in controls. Contrary to earlier reports, L:S allele frequencies ratio in elderly blood donors (EBDs) did not significantly differ from that in HBDs (0.49:0.51 and 0.54:0.46, respectively). However, the S allele had a tendency to be over‐represented among elderly compared with middle‐aged smokers (55% vs. 44%; OR = 1.57, 95% CI 0.98–2.50, p = 0.059), which implies that it may be linked with tolerance to smoking effects. Int. J. Cancer 85:747–750, 2000. © 2000 Wiley‐Liss, Inc.