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Seroepidemiology of human papillomavirus type 73: A sexually transmitted low‐risk virus
Author(s) -
Wallin KengLing,
van Doornum Gerard J.J.,
AnderssonEllström Agneta,
Kallings Ingegerd,
Wiklund Fredrik,
Hallmans Göran,
Schiller John,
Dillner Joakim
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(20000201)85:3<353::aid-ijc10>3.0.co;2-m
Subject(s) - medicine , seroprevalence , hpv infection , epidemiology , population , cervical cancer , antibody , risk factor , virology , human papillomavirus , virus , cancer , immunology , gynecology , serology , environmental health
Human papillomavirus type 73 (HPV 73) has been detected in some invasive cervical cancers and has been cloned from a squamous‐cell carcinoma of the esophagus, but the epidemiology of this infection and its associated risk of cancer is unknown. We investigated the seroepidemiology of this virus using virus‐like particles. The IgG response to HPV 73 appeared to be HPV type‐specific, since a comparison of HPV 73 antibody levels before and after infection with HPV 6, 11, 16, 18 or 33 found no evidence of cross‐induction of HPV 73 antibodies and since there was little correlation between the antibody levels to HPV 73 and the other 5 investigated HPV types. In both a cross‐sectional serosurvey that included 274 women and a 7‐year follow‐up study that enrolled 98 women, HPV 73 seropositivity was found to be strongly dependent on the number of lifetime sexual partners [OR for > 4 vs. 0 to 1 partners: 6.0 (95%CI: 1.4–53.6) and 7.9 (95% CI: 2.8–28.3), respectively]. Finally, the risk for HPV 73 seropositive women to develop CIN was investigated in a prospective study nested in a cohort of 15,234 Swedish women. The population‐based HPV 73 seroprevalence in Sweden was 14%. No excess risk for CIN was found (OR: 0.77). We conclude that HPV 73 is a mainly sexually transmitted, probably mostly transient, infection that does not confer any measurably increased risk for CIN development. Int. J. Cancer 85:353–357, 2000. ©2000 Wiley‐Liss, Inc.