Premium
Parental occupation and other factors and cancer risk in children: I. Study methodology and non‐occupational factors
Author(s) -
Smulevich Vladimir B.,
Solionova Liya G.,
Belyakova Svetlana V.
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19991210)83:6<712::aid-ijc2>3.0.co;2-d
Subject(s) - medicine , odds ratio , pregnancy , miscarriage , confidence interval , risk factor , population , breastfeeding , cancer , obstetrics , case control study , gynecology , pediatrics , demography , environmental health , genetics , sociology , biology
A population‐based case‐control study of risk factors for childhood cancer was conducted for 593 cases diagnosed over the period 1986–1988 in Moscow children 0 to 14 years of age. Two healthy controls to every case were selected from registers of local pediatric polyclinics by age, gender and residence. The parents of 593 cases and 1181 controls were interviewed face‐to‐face. Significantly higher odds ratios (OR) were associated with cancer in close relatives [OR 1.6; 95% confidence interval (CI) 1.3–1.9], any pathology associated with pregnancy (OR 2.9; 95% CI 2.4–3.6), including threatened miscarriage (OR 2.1; 95% CI 1.5–3.0), toxemia (OR 2.2; 95% CI 1.8–2.8) and hormone treatment during pregnancy (OR 2.2; 95% CI 1.0–4.5). Pre‐term births were significantly associated with brain‐cancer risk (6/1; OR 13.3; 95% CI 1.5–301.2). For low birth weight (≤2500 g) children born from full‐term pregnancy, the OR for all cancers combined was 2.5 (23/22; 95% CI 1.4–4.7) and for leukemias 4.7 (9/4; 95% CI 1.4–16.5). In all, 100 cases and 151 controls had birth weight ≥4000 g (OR 1.4; 95% CI 1.1–1.9). Risk of nephroblastoma was also significantly related to this factor (11/5; OR 5.1; 95% CI 1.6–16.4). A positive trend of OR with decreasing duration of breastfeeding was significant for all cancer combined ( p < 0.05). Significantly higher OR were observed for dermatitis (12/6; OR 4.0; 95% CI 1.4–12.1) and viral hepatitis (40/22; OR 3.8; 95% CI 2.3–6.3) in child medical history. Int. J. Cancer 83:712–717, 1999. © 1999 Wiley‐Liss, Inc.