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Attenuation by d ‐limonene of sodium chloride‐enhanced gastric carcinogenesis induced by N ‐methyl‐ N ′‐nitro‐ N ‐nitrosoguanidine in Wistar rats
Author(s) -
Yano Hiroyuki,
Tatsuta Masaharu,
Iishi Hiroyasu,
Baba Miyako,
Sakai Noriko,
Uedo Noriya
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990827)82:5<665::aid-ijc8>3.0.co;2-e
Subject(s) - carcinogen , chemistry , endocrinology , sodium , medicine , apoptosis , ornithine decarboxylase , biochemistry , enzyme , organic chemistry
Abstract The effects of prolonged administration of d ‐limonene, a monocyclic monoterpene, on sodium chloride‐enhanced induction of gastric carcinogenesis by N ‐methyl‐ N ′‐nitro‐ N ‐nitrosoguanidine, the labeling and apoptotic indices, and ornithine decarboxylase (ODC) activity of gastric cancers were investigated in Wistar rats. After 25 weeks of carcinogen treatment, rats were given chow pellets containing 10% sodium chloride and 1% limonene ad libitum. In week 52, the incidence of gastric cancers, the labeling index and ODC activity were significantly higher and the apoptotic index was significantly lower in rats given sodium chlolide than in untreated control rats. However, in rats given both sodium chloride and d ‐limonene, the incidence of gastric cancers, the labeling index and ODC activity were significantly lower and the apoptotic index was significantly higher than in rats given sodium chloride alone. Our findings suggest that limonene attenuates the gastric carcinogenesis enhanced by sodium chloride via increased apoptosis and decreased ODC activity in gastric cancers. Int. J. Cancer 82:665–668, 1999. © 1999 Wiley‐Liss, Inc.