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Different patterns of chromosomal imbalances in metastasising and non‐metastasising primary breast carcinomas
Author(s) -
Adeyinka Adewale,
Mertens Fredrik,
Idvall Ingrid,
Bondeson Lennart,
Ingvar Christian,
Mitelman Felix,
Pandis Nikos
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990820)84:4<370::aid-ijc7>3.0.co;2-7
Subject(s) - chromosome , biology , breast cancer , breast tumours , phenotype , breast carcinoma , node (physics) , cancer research , mammary gland , cancer , pathology , oncology , genetics , medicine , gene , structural engineering , engineering
In an attempt to identify chromosomal abnormalities that may be associated with a metastatic phenotype, we investigated the pattern of chromosomal gains and losses in 66 node‐positive and 63 node‐negative primary breast carcinomas. For both subgroups of tumours, losses were more common than gains and the losses were most often the result of structural aberrations. The exceptions were the long arm of chromosome 1, and chromosomes 7, 8, 12, 18 and 20, which were more often gained than lost. Node‐negative tumours were preferentially characterised by loss of 6q10–21 and loss of 16q, whereas loss of chromosome 18 was significant for node‐positive tumours. Other aberrations that tended to be associated with one of the phenotypes, though not statistically significant, were gain of chromosome 18 and loss of chromosome 10 in node‐negative tumours, and gain of chromosome 14 and loss of 12p in node‐positive tumours. Our data show that there are differences among the genetic lesions present in node‐negative and node‐positive breast tumours. Int. J. Cancer (Pred. Oncol.) 84:370–375, 1999. © 1999 Wiley‐Liss, Inc.