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Synovial sarcoma specific translocation associated with both epithelial and spindle cell components
Author(s) -
Birdsall Sandra,
Osin Pinchas,
Lu YongJie,
Fisher Cyril,
Shipley Janet
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990812)82:4<605::aid-ijc22>3.0.co;2-h
Subject(s) - synovial sarcoma , chromosomal translocation , pathology , sarcoma , spindle cell sarcoma , biology , medicine , cancer research , anatomy , genetics , gene
The biphasic subtype of synovial sarcoma consists of both epithelial and spindle cell components. To address the relationship between the different cellular components found in synovial sarcoma, we deduced the presence of the synovial sarcoma‐specific der(X)t(X;18)(p11.2;q11.2), and involvement of the SSX1 gene in both the epithelial/glandular and spindle cell components of 3 biphasic synovial sarcomas with wide ranging proportions of each of the 2 elements. This has been achieved using a 2‐color fluorescence in situ hybridization (FISH) methodology that we had developed recently for analysis paraffin‐embedded material. The presence of the rearrangement could be deduced in histologically defined regions and the results showed clearly that the rearrangement was present in both cellular components. This finding provides direct genetic evidence for biphasic synovial sarcomas being clonal and truly biphasic. Int. J. Cancer 82:605–608, 1999. © 1999 Wiley‐Liss, Inc.