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Cancer incidence and mortality in a cohort of chloroprene workers from Armenia
Author(s) -
Bulbulyan Mariana A.,
Margaryan Anait G.,
Ilychova Svetlana A.,
Astashevsky Sergey V.,
Uloyan Sirush M.,
Cogan Vladimir Y.,
Colin Didier,
Boffetta Paolo,
Zaridze David G.
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990331)81:1<31::aid-ijc6>3.0.co;2-t
Subject(s) - chloroprene , standardized mortality ratio , incidence (geometry) , medicine , cohort , cancer , confidence interval , cohort study , liver cancer , cancer incidence , cumulative incidence , chemistry , natural rubber , physics , organic chemistry , optics
We evaluated the risk of cancer among 1897 men and 417 women exposed to chloroprene (2‐chloro‐1,3‐butadiene, CP) at a production plant in Yerevan, Armenia, between 1940 and 1988. The cohort was followed up for cancer incidence for the years 1979–1990 and for cancer mortality for 1979–1988. In the cohort, incidence and mortality from all cancers were below expectation, but increased incidence (standardized incidence ratio 3.27, 95% confidence interval [CI] 1.47–7.27), and mortality (standardized mortality ratio 3.39, 95% CI 1.09–10.5) from liver cancer were noticed. A dose–response relationship was suggested between liver cancer and indices of CP exposure, such as duration of employment, duration of high CP exposure and cumulative exposure to CP. The risk of other neoplasms was not increased. Int. J. Cancer 81:31–33, 1999. © 1999 Wiley‐Liss, Inc.