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Leptin in relation to carcinoma In situ of the breast: A study of pre‐menopausal cases and controls
Author(s) -
Mantzoros Christos S.,
Bolhke Kari,
Moschos Stergios,
Cramer Daniel W.
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990209)80:4<523::aid-ijc7>3.0.co;2-c
Subject(s) - medicine , leptin , in situ , gynecology , menopause , physiology , obesity , geography , meteorology
Leptin reflects the amount of energy stores, regulates energy balance and is associated with circulating levels of reproductive hormones and insulin‐like growth factor‐I (IGF‐I). Breast cancer has also been associated with obesity, reproductive hormones and circulating IGF‐I levels. To determine whether leptin is involved in the etiology of breast cancer, we compared serum leptin levels in 83 cases of pre‐menopausal carcinoma in situ of the breast and 69 healthy controls recruited in Massachusetts. Serum leptin levels were 13.69 + 1.3 ng/ml in cases and 16.03 + 1.7 ng/ml in controls. Data were also analyzed using multiple logistic regression with adjustment for known risk factors for the development of breast cancer as well as anthropometric, demographic and hormonal variables, including estradiol, prolactin, IGF‐I and IGF‐binding protein‐3. Odds ratios were 1.75 (95% CI, 0.73–4.21) for the second control‐defined tertile and 1.54 (0.46–5.16 ) for the third control‐defined tertile relative to the first. Thus, leptin does not appear to increase the risk of pre‐menopausal breast cancer in situ substantially. Int. J. Cancer 80:523–526, 1999. © 1999 Wiley‐Liss, Inc.