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Prospective study on cervical neoplasia IV. Presence of HPV antibodies
Author(s) -
Vonka Vladimír,
Hamšíková Eva,
Kaňka Jirí,
Ludvíková Viera,
Sapp Martin,
Šmahel Michal
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990129)80:3<365::aid-ijc5>3.0.co;2-c
Subject(s) - medicine , antibody , prospective cohort study , virology , immunology
Sera collected in the course of a prospective study carried out in Prague in 1975–1983 were assayed for the presence of human papillomavirus (HPV) antibodies. Women with cervical neoplasia proven by biopsy at enrollment possessed antibodies to peptides derived from E2, E4 and E7 proteins of HPV16 and to virus‐like particles (VLPs) of HPV16, ‐18 and ‐33 significantly more frequently than matched controls. Women without cervical neoplasia at enrollment who developed the disease in the course of the study differed from matched controls by a higher prevalence of antibodies against VLPs of HPV16 and ‐18 but not against early antigens of HPV16. In 19 of the latter subjects, paired serum specimens were tested, the first samples having been taken at enrollment and the second at diagnosis. Development of the disease was associated with seroconversion from negativity to positivity to at least one HPV antigen in 11 (57.9%) women. Int. J. Cancer 80:365–368, 1999. © 1999 Wiley‐Liss, Inc.