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Tobacco, occupation and non‐transitional‐cell carcinoma of the bladder: An international case‐control study
Author(s) -
Fortuny Joan,
Kogevinas Manolis,
ChangClaude Jenny,
González CarlosAlberto,
Hours Martine,
Jöckel KarlHeinz,
BolmAudorff Ulrich,
Lynge Elsebeth,
‘T Mannetje Andrea,
Porru Stefano,
Ranft Ulrich,
Serra Consol,
Tzonou Anastasia,
Wahrendorf Jürgen,
Boffetta Paolo
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990105)80:1<44::aid-ijc9>3.0.co;2-8
Subject(s) - medicine , odds ratio , bladder cancer , transitional cell carcinoma , confidence interval , urinary bladder , case control study , population , oncology , carcinoma , cancer , environmental health
Transitional‐cell carcinoma is the dominant histological type of malignant tumors of the urinary bladder. There is limited information on risk factors for non‐transitional‐cell carcinoma (NTCC) of the bladder. We used data from 9 case‐control studies on bladder cancer from 6 European countries to examine the association between NTCC, tobacco smoking and occupation. Information on 146 cases diagnosed with NTCC were matched by age, gender and study center to 727 non‐cancer population or hospital controls and also with 722 transitional‐cell‐bladder‐cancer controls. Lifetime smoking and occupational history were evaluated. A statistically significant excess risk for NTCC was observed for current smoking [odds ratio (OR) = 3.61, 95% confidence interval (CI) 2.08–6.28]. The risk increased with higher tobacco consumption (OR for highest tertile of pack‐years = 7.01, 95% CI 3.60–13.66). The risks were higher for squamous‐cell carcinomas than for other types of NTCC. Among major occupational groups, a significant excess risk was seen for field‐crop and vegetable‐farm workers (OR = 2.06, 95% CI 1.03–4.10). These results indicate that NTCC of the bladder is associated with smoking and specific occupations. The risk pattern seems to differ, in part, from that observed for transitional‐cell carcinoma of the bladder. Int. J. Cancer 80:44–46, 1999. © 1999 Wiley‐Liss, Inc.