Premium
Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus
Author(s) -
Smida Jan,
Salassidis Konstadinos,
Hieber Ludwig,
Zitzelsberger Horst,
Kellerer Albrecht M.,
Demidchik Eugene P.,
Negele Thomas,
Spelsberg Fritz,
Lengfelder Edmund,
Werner Martin,
Bauchinger Manfred
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990105)80:1<32::aid-ijc7>3.0.co;2-l
Subject(s) - papillary carcinoma , thyroid carcinoma , medicine , thyroid , pathology , oncology
Rearrangements of the ret oncogene were investigated in papillary thyroid carcinomas (PTC) from 51 Belarussian children with a mean age of 3 years at the time of the Chernobyl radiation accident. For comparison, 16 PTC from exposed Belarussian adults and 16 PTC from German patients without radiation history were included in the study. ret rearrangements were detected and specified by RT‐PCR and direct sequencing using specific primers for ret /PTC1, 2 and 3. Only ret /PTC1, and no ret /PTC3, was found in the adult patients, with a frequency of 69% for the Belarussian cases, but of only 19% in the German patients. In contrast, 13 ret /PTC3 (25.5%) and 12 ret /PTC1 (23.5%) rearrangements were present in PTC from Belarussian children. Thus, our study reveals about a 1:1 ratio of ret /PTC3 and ret /PTC1, in contrast to earlier studies with lower numbers of cases and exhibiting a high predominance of ret /PTC3 (ratio about 3:1). A ratio (2.5:1) similar to that in earlier investigations (diagnosed 1991–94) was obtained for cases included in our study that were diagnosed in 1993/94. The present data suggest that ret /PTC3 may be typical for radiation‐associated childhood PTC with a short latency period, whereas ret /PTC1 may be a marker for later‐occurring PTC of radiation‐exposed adults and children. Int. J. Cancer 80:32–38, 1999. © 1999 Wiley‐Liss, Inc.