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Frequent allelic loss and homozygous deletion in chromosome band 8p23 in oral cancer
Author(s) -
Ishwad Chandramohan S.,
Shuster Michele,
Bockmühl Ulrike,
Thakker Nalin,
Shah Punit,
Toomes Carmel,
Dixon Michael,
Ferrell Robert E.,
Gollin Susanne M.
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990105)80:1<25::aid-ijc6>3.0.co;2-g
Subject(s) - loss of heterozygosity , biology , carcinogenesis , allele , tumor suppressor gene , cancer research , cancer , chromosome , gene , genetics , epidermoid carcinoma , pathogenesis , microsatellite , head and neck squamous cell carcinoma , head and neck cancer , immunology
Frequent loss of heterozygosity on chromosome 8p in a variety of human malignancies, including head and neck cancers, has suggested the presence of a tumor suppressor gene (or genes) associated with the pathogenesis of these cancers. To test the role of genetic alterations at 8p23 in oral carcinogenesis, we studied 51 squamous cell carcinomas of the head and neck and 29 oral squamous cell carcinoma cell lines for allelic loss using 7 microsatellite markers spanning approximately 5 cM of chromosome band 8p23. Twenty‐three of 51 tumors (45%) and 23 of 29 cell lines (79%) showed allelic loss at 1 or more loci. Three cell lines showed homozygous deletion of loci within a 3 cM region defined by the markers D8S1781 and D8S262. Our results suggest that a tumor suppressor gene (or genes) is located in 8p23 and is associated with the development and/or progression of oral carcinomas. Int. J. Cancer 80:25–31, 1999. © 1999 Wiley‐Liss, Inc.