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Microsatellite analysis reveals deletion of a large region at chromosome 8p in conventional renal cell carcinoma
Author(s) -
Schullerus Dietlinde,
von Knobloch Rolf,
Chudek Jerzy,
Herbers Jutta,
Kovacs Gyula
Publication year - 1999
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19990105)80:1<22::aid-ijc5>3.0.co;2-s
Subject(s) - loss of heterozygosity , locus (genetics) , biology , microsatellite , deletion mapping , chromosome , chromosome 3 , genetics , chromosome 9 , gene , renal cell carcinoma , microbiology and biotechnology , cancer research , pathology , allele , medicine
Loss of heterozygosity (LOH) at chromosome 8p is associated with the progression of conventional (non‐papillary) renal cell carcinomas (RCC). To determine the tumor suppressor gene locus, we carried out a deletion mapping of chromosome 8p at 10 microsatellite loci in 96 RCCs. LOH occurred in 32% of the tumors. The smallest overlapping region of deletion at chromosome 8p11.2–p23.1 corresponds to approximately 34‐cM genetic distance. No small interstitial deletion was seen. Int. J. Cancer 80:22–24, 1999. © 1999 Wiley‐Liss, Inc.