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nm23‐H1 expression in nasopharyngeal carcinoma: correlation with clinical outcome
Author(s) -
Guo Xiang,
Min Huaqing,
Zeng Musheng,
Qian Chaonan,
Huang Xiaoming,
Shao Jianyong,
Hou Jinghui
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19981218)79:6<596::aid-ijc7>3.0.co;2-y
Subject(s) - nasopharyngeal carcinoma , carcinoma , correlation , oncology , medicine , outcome (game theory) , pathology , radiation therapy , mathematics , geometry , mathematical economics
The expression levels of nm23‐H1 mRNA and its protein in human nasopharyngeal carcinoma (NPC) were detected to clarify the relationship between nm23‐H1 and metastasis and prognosis of patients with NPC. nm23‐H1 mRNA expression in fresh tissues from 78 patients with NPC was investigated by in situ hybridization and RT‐PCR. Routine labeling streptavidin‐biotin immuno‐histochemistry with the nm23‐H1 murine monoclonal antibody was employed to study the expression of nm23‐H1 protein in paraffin‐embedded specimens from 231 patients with NPC treated in our hospital. The clinical pathologic data and results of follow‐up were collected. Comparisons between expression of nm23‐H1 protein or mRNA and clinical outcome were performed using the χ 2 test. Multivariate prognostic analyses were performed by the Cox regression model. We found that nm23‐H1‐negative tumors were associated with a higher incidence of lymph‐node metastasis (84.2%) than nm23‐H1‐positive ones (32.8%, p < 0.01). The distant metastasis and loco‐regional recurrence rates in the nm23‐H1‐negative group were 55.8% and 31.68%, respectively but only 17.2% and 11.5%, respectively, in the nm23‐H1‐positive group ( p < 0.01). A significant association was found between expression of nm23‐H1 protein and prognosis ( p < 0.01). Expression of nm23‐H1 protein indicated favorable prognosis, suggesting that the absence of nm23‐H1 protein expression was significantly associated with lymph‐node metastasis, recurrence and distant metastasis in NPC. Expression of the nm23‐H1 gene may be valuable for assessing the prognosis of NPC. Int. J. Cancer (Pred. Oncol.) 79:596–600, 1998. © 1998 Wiley‐Liss, Inc.