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Non‐invasive estimation of the circadian rhythm in serum cortisol in patients with ovarian or colorectal cancer
Author(s) -
Mormont MarieChristine,
Hecquet Bernard,
Bogdan André,
Benavides Manuel,
Touitou Yvan,
Lévi Francis
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19981109)78:4<421::aid-ijc5>3.0.co;2-w
Subject(s) - circadian rhythm , chronotherapy (sleep phase) , medicine , colorectal cancer , blood sampling , ovarian cancer , rhythm , oncology , cancer , hydrocortisone , physiology , endocrinology
The variability in toxicity or efficacy of cancer chronotherapy among patients may be due to differences in circadian rhythm. Adequate assessment of circadian rhythm often requires repeated blood sampling over at least a 24‐hr period; this cannot be a routine procedure. We attempted to assess the reliability of a 2‐timepoint estimate of the 24‐hr rhythm of serum cortisol in 19 healthy subjects, 19 women with ovarian cancer and 18 patients with metastatic colorectal cancer. The difference between daily maximum and minimum values (MAX–MIN) was compared with that observed between values at 08.00 and at 16.00 (H8–H16). As significant correlations were found between both variables in all groups, we conclude that the magnitude of circadian changes in serum cortisol may be estimated from blood samples collected at 08.00 and at 16.00. The clinical relevance and the prognostic value of this method of assessment are currently under evaluation in a larger‐scale clinical trial. Int. J. Cancer 78:421–424, 1998.© 1998 Wiley‐Liss, Inc.