Premium
Association between genetic polymorphisms of glutathione S ‐transferase P1 and N ‐acetyltransferase 2 and susceptibility to squamous‐cell carcinoma of the esophagus
Author(s) -
Morita Shunji,
Yano Masahiko,
Tsujinaka Toshimasa,
Ogawa Atsuhiro,
Taniguchi Masaaki,
Kaneko Katsuhiko,
Shiozaki Hitoshi,
Doki Yuichiro,
Inoue Masatoshi,
Monden Morito
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19981023)79:5<517::aid-ijc12>3.0.co;2-z
Subject(s) - gstp1 , genotype , esophagus , odds ratio , gastroenterology , biology , carcinoma , epidermoid carcinoma , medicine , esophageal cancer , genetic predisposition , oncology , cancer , genetics , gene
We examined the effect of genetic polymorphisms of phase‐II enzymes, glutathione S ‐transferase P1 ( GSTP1 ) and N ‐acetyltransferase2 ( NAT2 ) on susceptibility to esophageal squamous‐cell carcinoma. To determine the genotypes of the 2 polymorphisms, PCR‐based analysis was performed on samples from 66 Japanese patients who had been histologically diagnosed as having esophageal squamous‐cell carcinoma, and 164 healthy Japanese controls. The frequency of the AA genotype of GSTP1 was significantly higher in esophageal‐cancer patients than in the controls according to logistic‐regression analysis (92% of the patients and 68% of the controls; odds ratio (OR), 8.0; p = 0.0013). Also, more patients had the slow and intermediate acetylator genotypes of NAT2 than the controls (15% and 38% vs. 10% and 32% respectively; OR of the slow acetylator genotype, 4.2; p = 0.032; OR of the slow plus intermediate acetylator genotypes, 2.9; p = 0.015). Polymorphisms of GSTP1 and NAT2 may serve as genetic biomarkers for predicting susceptibility to esophageal squamous‐cell carcinoma. Int. J. Cancer (Pred. Oncol.) 79:517–520, 1998.© 1998 Wiley‐Liss, Inc.