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Chromosome 5 aberrations and genetic predisposition to lung cancer
Author(s) -
Wu Xifeng,
Zhao Yin,
Kemp Bonnie L.,
Amos Christopher I.,
Siciliano Michael J.,
Spitz Margaret R.
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19981023)79:5<490::aid-ijc8>3.0.co;2-w
Subject(s) - lung cancer , bleomycin , cancer , chromosome , population , medicine , pathology , lung , biology , respiratory disease , oncology , genetics , gene , chemotherapy , environmental health
In this study, we aimed to confirm the finding that chromosome 5 aberrations are predisposing factors for lung cancer. The study population consisted of 118 previously untreated lung cancer patients and 101 healthy controls. Lymphocytes were treated with bleomycin for 5 hr and then allowed to recover in a drug‐free medium for 48 hr. The mean number of cells with chromosome 5 abnormalities among 100 cells examined was significantly higher in patients (9.12) than in controls (4.69) ( p < 0.001). The most frequent aberration was a 5q deletion and the breakpoints clustered at the 5q13‐5q31 region. We then dichotomized the number of induced chromosome 5 abnormalities in peripheral blood lymphocytes by the 75th percentile in that of the controls. 103 (87.3%), of the 118 patients, but only 31 (30.7%) of the 101 controls, exhibited induced breaks above this point. After adjustment for age, sex, ethnicity and smoking status, we found that the sensitive group was at 14.4‐fold increased risk for lung cancer. There was also a significant ( p < 0.01) gradient of increased risk for lung cancer with an increasing number of chromosome 5 lesions. Therefore, chromosome 5 lesions, especially those at 5q, may be a molecular target of carcinogens in the development of lung cancer. Int. J. Cancer (Pred. Oncol.) 79:490–493, 1998.© 1998 Wiley‐Liss, Inc.