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cag A‐positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil
Author(s) -
Queiroz Dulciene M. M.,
Mendes Edilberto N.,
Rocha Gifone A.,
Oliveira Andreia M. R.,
Oliveira Celso A.,
Magalhães Paula P.,
Moura Sílvia B.,
Cabral Mônica M. D. A.,
Nogueira Ana M. M. F.
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19981005)78:2<135::aid-ijc1>3.0.co;2-#
Subject(s) - helicobacter pylori , gastric carcinoma , gastroenterology , medicine , carcinoma , spirillaceae , stomach , cancer , biopsy , pathology , gastritis
To evaluate a possible association between infection with cag A‐positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori ‐positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A‐positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A‐positive status and proximal gastric carcinoma. Int. J. Cancer 78:135–139, 1998.© 1998 Wiley‐Liss, Inc.