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Elevated serum level of soluble CD23 precedes development of B‐non‐Hodgkin's lymphoma in SIV‐infected rhesus monkeys
Author(s) -
Hannig Horst,
Buske Christian,
MätzRensing Kerstin,
Hunsmann Gerhard,
Hiddemann Wolfgang,
Bodemer Walter
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980831)77:5<734::aid-ijc12>3.0.co;2-1
Subject(s) - lymphoma , cd23 , simian immunodeficiency virus , immunology , b cell , medicine , group b , in vivo , non hodgkin's lymphoma , biology , virus , immunoglobulin e , antibody , microbiology and biotechnology
Patients with HIV infection are at high risk for the development of high‐grade B‐non‐Hodgkin's lymphoma (B‐NHL). The aim of this study was identification of a predictive diagnostic marker for HIV‐associated B‐cell lymphomas, using simian‐immunodeficiency‐virus (SIV)‐infected Rhesus monkeys as a well‐established in vivo model of HIV‐associated lymphomagenesis. We infected 26 monkeys ( Macaca mulatta ) with SIV mac and measured serum levels of sCD23 longitudinally until necropsy. Of the 26 monkeys, 9 developed high‐grade B‐NHL, which was preceded by lymphadenopathy (NHL + /LA + ) (group 1). Among the 17 animals that remained without clinical evidence of lymphoma during the observation period, 8 developed LA (group 2) and 9 were NHL‐ and LA‐negative (NHL − /LA − ) (group 3). Elevation of sCD23 serum levels preceded B‐cell lymphoma development, with a median of 44 U/ml in group 1 vs. 7 U/ml and 8 U/ml in groups 2 and 3 respectively, 32 weeks after infection. Differences in the serum level of sCD23 between group 1 vs. groups 2 and 3 became statistically significant 32 to 56 weeks after infection. At necropsy, serum levels of sCD23 were significantly higher in group 1 than in group 2 or group 3; 6/6 samples of SIV‐associated B‐NHL were positive for gene transcription of CD23 and its receptor CD21 as assessed by RT‐PCR. The data point to a potential role of sCD23 as a predictive marker for the development of HIV‐associated B‐NHL. Moreover, the in vivo model of SIV‐infected monkeys suggests the possibility of exactly analyzing the pathobiological role of sCD23 in the lymphomagenesis of SIV‐associated B‐NHL. Int. J. Cancer 77:734–740, 1998. © 1998 Wiley‐Liss, Inc.