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Prognostic significance of p53 protein overexpression in betel‐ and tobacco‐related oral oncogenesis
Author(s) -
Kaur Jasbir,
Srivastava Anurag,
Ralhan Ranju
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980821)79:4<370::aid-ijc11>3.0.co;2-9
Subject(s) - carcinogenesis , malignancy , medicine , cancer , dysplasia , carcinoma , betel , pathology , metastasis , univariate analysis , gastroenterology , oncology , multivariate analysis , structural engineering , nut , engineering
We have previously reported overexpression of p53 protein in tobacco‐related oral dysplasia and squamous cell carcinoma (SCC) in the Indian population. A follow‐up study was carried out to determine the prognostic significance of an accumulation of p53 protein during oral tumorigenesis. One hundred and two of 145 (70%) of oral SCCs and 39/75 (52%) of oral dysplasias showed overexpression of p53 protein, while only 3 of 107 (3%) normal oral tissues showed a detectable level of the protein. Follow‐up studies of these patients suggest that an accumulation of p53 protein may be involved in the early phases of oral SCC development and indicate the predisposition of a particular premalignant lesion towards malignancy. In patients with premalignant lesions, the median transition time (premalignancy to malignancy) was significantly shorter in p53 positive cases than in p53 negative cases ( p = 0.013). Among the oral cancer patients, univariate analysis showed that alteration in p53 expression was associated with significantly decreased disease‐free survival. The p53 positive cases showed decreased median disease‐free survival time (no recurrence/metastasis) compared with the p53 negative cases ( p = 0.013), indicating that p53 accumulation may serve as a prognostic indicator in oral cancer patients. Int. J. Cancer (Pred. Oncol.) 79:370–375, 1998. © 1998 Wiley‐Liss, Inc.