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Cytogenetic findings in invasive breast carcinomas with prognostically favourable histology: A less complex karyotypic pattern?
Author(s) -
Adeyinka Adewale,
Mertens Fredrik,
Idvall Ingrid,
Bondeson Lennart,
Ingvar Christian,
Heim Sverre,
Mitelman Felix,
Pandis Nikos
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980821)79:4<361::aid-ijc9>3.0.co;2-t
Subject(s) - medullary cavity , pathology , biology , mucinous carcinoma , chromosomal translocation , karyotype , cytogenetics , medullary carcinoma , histology , carcinoma , breast cancer , cancer , chromosome , adenocarcinoma , medicine , endocrinology , genetics , thyroid , thyroid carcinoma , gene
Seventeen invasive primary breast carcinomas of histological types usually considered to be prognostically favourable (2 medullary, 3 papillary, 3 tubular, and 9 mucinous carcinomas) were analysed as part of an ongoing study of the cytogenetics of breast cancer. Thirteen of the tumours (7 mucinous, 2 medullary, 2 papillary, and 2 tubular carcinomas) showed clonal chromosome aberrations. Trisomy 7 and i(1q) were present as sole and recurrent aberrations in the mucinous tumours. The 2 tubular carcinomas and 1 papillary carcinoma had simple numerical changes only, whereas the second papillary tumour had a balanced translocation as the sole anomaly. Both medullary carcinomas had chromosome numbers in the triploid range, with clones displaying structural and numerical changes. Our data, especially when collated with information on previously published cases of mucinous, papillary, tubular, and medullary breast carcinomas, show that the former 3 histological types, in keeping with their recognised prognostic advantage, appear to exhibit relatively simple karyotypic changes, i.e., numerical aberrations, balanced translocations, and near‐diploid chromosome numbers. Medullary carcinomas on the other hand, appear to have more complex karyotypes, similar to those described for the more common ductal and lobular subtypes of breast carcinoma. Int. J. Cancer (Pred. Oncol.) 79:361–364, 1998. © 1998 Wiley‐Liss, Inc.