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Nasopharyngeal carcinoma in Malaysian Chinese: Salted fish and other dietary exposures
Author(s) -
Armstrong R. Warwick,
Imrey Peter B.,
Lye Munn Sann,
Armstrong M. Jocelyn,
Yu Mimi C.,
Sani Sham
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980717)77:2<228::aid-ijc11>3.0.co;2-7
Subject(s) - salted fish , nasopharyngeal carcinoma , shrimp , biology , fish <actinopterygii> , population , leafy vegetables , food science , medicine , environmental health , fishery , surgery , radiation therapy
We interviewed 282 histologically confirmed cases of nasopharyngeal carcinoma (NPC) in Chinese residents of Selangor and the Federal Territory, Malaysia, and an equal number of Chinese age‐, sex‐, and length‐of‐residence‐matched controls sampled from the general population. Consumption of 55 dietary items during childhood, and 5 years pre‐diagnosis of NPC, was analyzed by univariate and multivariate methods. Four salted preserved foods (fish, leafy vegetables, egg and root), fresh pork/beef organ meats and beer and liquor consumption exhibited strong positive associations, and 4 vegetable/fruit combinations strong negative associations with NPC. Factor analysis and multivariable modeling using estimated factor scores strongly supported separate effects on NPC of vegetables/fruits, salted preserved foods, pork/beef organ meats and beer/liquor consumption. Multivariable modeling associated NPC most clearly with high consumption of salted fish, salted eggs, pork/beef liver and beer and low consumption of Chinese flowering cabbage, oranges/tangerines and shrimp. A strong residual association of social class with NPC remained after adjustment for diet, which is consistent with a substantial role for non‐dietary environmental factors. Int. J. Cancer 77:228–235, 1998.© 1998 Wiley‐Liss, Inc.