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Predictors of level of circulating abnormal lymphocytes among human T‐lymphotropic virus type I carriers in Japan
Author(s) -
Hisada Michie,
Okayama Akihiko,
Tachibaobuyoshi,
Stuver Sherri O.,
Spiegelman Donna L.,
Tsubouchi Hirohito,
Mueller Nancy E.
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980717)77:2<188::aid-ijc3>3.0.co;2-m
Subject(s) - asymptomatic carrier , asymptomatic , titer , immunology , leukemia , human t lymphotropic virus 1 , virology , virus , medicine , biology , t cell leukemia
Human T‐lymphotropic virus type I (HTLV‐I) carriers often have abnormal lymphocytes (Ably) that resemble malignant cells of adult T‐cell leukemia (ATL). To identify predictors of the level of Ably in a longitudinal study of asymptomatic HTLV‐I carriers, we analyzed data from 215 subjects (67 men and 148 women) with multiple Ably measurements on blood smears. Ably + (those having Ably > 0.6% of leukocytes counted on a blood smear at least once) was strongly associated with a high proviral<0B> <0R>load (OR 8.9; 95% CI 4.1, 19.5).<0B> <0R>The association among those defined as Ably ++ (Ably > 0.6% at all screens or Ably > 1.6% at least once) was higher (19.7; 6.9, 56.1). Ably ++ was also significantly associated with male gender (2.8; 1.0, 7.8). Multivariate analysis of Ably level indicates<0B> <0R>that men with a high proviral load, high anti‐HTLV‐I titer and low anti‐Tax reactivity have the highest Ably level. Int. J. Cancer 77:188–192, 1998.© 1998 Wiley‐Liss, Inc.