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Risk factors for endometrial cancer according to familial susceptibility
Author(s) -
Fornasarig Mara,
Campagnutta Elio,
Talamini Renato,
Franceschi Silvia,
Boz Gianni,
Scarabelli Carlo,
Maria Andreaus Cristina,
Scozzari Giovanni,
Valentini Maurizio
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980703)77:1<29::aid-ijc6>3.0.co;2-1
Subject(s) - endometrial cancer , medicine , cancer , gynecology , oncology , obstetrics
Endometrial cancer (EC) shares some environmental or genetic risk factors with colorectal cancer (CRC). It represents a risk factor for CRC. Furthermore, EC is the most frequent extracolonic neoplasm in HNPCC (hereditary nonpolyposis colorectal cancer) and, in this syndrome, it has the same inheritance pattern as CRC. Neoplastic family history and clinical features were evaluated in women with EC in a health care district (Pordenone Province) in Northeastern Italy from 1990 to 1995, to examine the proportion of patients with hereditary cancer and the relation with clinical characteristics of EC. We interviewed 215 patients with EC (average age 61 years, range 35–88) in relation with some risk factors (age, weight, diabetes, menstrual and reproductive pattern, synchronous and metachronous neoplasms) and we obtained their family pedigree. Twenty‐nine patients (13.5%) had a CRC family history, 66 (30.7%) showed an aspecific cancer aggregation in their families and more than half (120, 55.8%) had a negative cancer family history. Family pedigrees were consistent with a dominant inherited cancer pattern in 8 patients (3.7%) belonging to the CRC‐related family history group. A different pattern of family history distribution emerged in relation with age (<55 vs. ≥55, p < 0.001) and body mass index (BMI) (<26 vs. ≥26, p = 0.002). Patients with a CRC pedigree were more numerous in the younger group, in the group with lower BMI and in pre‐menopausal women. Int. J. Cancer 77:29–32, 1998.© 1998 Wiley‐Liss, Inc.