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Family aggregation of carcinoma of the hypopharynx and cervical esophagus: Special reference to multiplicity of cancer in upper aerodigestive tract
Author(s) -
Morita Masaru,
Kuwano Hiroyuki,
Nakashima Tadashi,
Taketomi Akinobu,
Baba Hideo,
Saito Takao,
Tomoda Hirotsugu,
Egashira Akinori,
Kawaguchi Hidetoshi,
Kitamura Kaoru,
Sugimachi Keizo
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980518)76:4<468::aid-ijc4>3.0.co;2-p
Subject(s) - family history , medicine , cancer , odds ratio , esophagus , cervical cancer , esophageal cancer , oncology , gynecology
The role of family history in the multiple occurrence of cancer in the upper aerodigestive tract (UADT) remains unclear. The family histories of close relatives were examined in 167 patients with either hypopharyngeal or cervical esophageal cancer (PhCe cancer) and in 167 control subjects with benign diseases. The odds ratio for PhCe cancer was 2.6 in relation to family history of UADT cancers. Based on the family histories of close relatives, 167 cases with PhCe cancer were divided into 3 groups (Group I, 18 cases with a family history of UADT cancer; Group II, 37 cases with a family history of other cancers; Group III, 112 cases with no family history of any cancers). The mean age of the cases in group I was 59.4, which was younger than in group III (64.2). Second primary squamous‐cell carcinomas in the UADT were more frequently recognized in group I (39%) than in group III (11%). However, no differences were observed in the smoking and drinking habits of male patients between each group. These results thus suggest that a family history of UADT cancers appears to be associated with the multiple occurrence of UADT cancers as well as the development of PhCe cancer. Int. J. Cancer 76:468‐471, 1998.© 1998 Wiley‐Liss, Inc.