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Trends in seroprevalence of human papillomavirus type 16 among pregnant women in Stockholm, Sweden, during 1969–1989
Author(s) -
Af Geijersstam Veronika,
Wang Zhaohui,
LewensohnFuchs Ilona,
Eklund Carina,
Schiller John T.,
Forsgren Marianne,
Dillner Joakim
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980504)76:3<341::aid-ijc10>3.0.co;2-e
Subject(s) - seroprevalence , human papillomavirus , medicine , epidemiology , demography , gynecology , virology , obstetrics , immunology , serology , antibody , sociology
To assess long‐term trends in the prevalence of oncogenic human papillomavirus (HPV) infection, we performed a cross‐sectional serosurvey of the seroprevalence of the major oncogenic HPV type, HPV16, among 3,512 pregnant women undergoing population‐based serological screening at the first trimester of pregnancy in the same catchment area in Stockholm, Sweden, during 1969, 1983 or 1989. The overall HPV16 seroprevalence rates were 16% in 1969, 22% in 1983 and 21% in 1989. Seroprevalence was significantly increased, comparing both 1969 vs. 1983 ( p = 0.0005) and 1969 vs. 1989 ( p = 0.008). By comparison, the previously reported herpes simplex 2 (HSV‐2) seroprevalence in the same women increased from 17% in 1969 to 32% in 1983 and 33% in 1989, whereas the seroprevalence rates of HSV‐1 were the same (69% in 1969, 63% in 1983 and 68% in 1989). Odds ratios for HPV16‐positive women to also be HSV‐2‐positive were 1.8 in 1969 ( p < 0.005), 1.1 in 1983 ( p = NS) and 1.0 in 1989. Our results suggest that both HSV‐2 and HPV16 became more generally spread in the Swedish population between 1969 and 1983 but that the spread has been stable during the 1980s. Int. J. Cancer 76:341–344, 1998.© 1998 Wiley‐Liss, Inc.