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p53, vessel count, and vascular endothelial growth factor expression in human colon cancer
Author(s) -
Takahashi Yutaka,
Bucana Corazon D.,
Cleary Karen R.,
Ellis Lee M.
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980220)79:1<34::aid-ijc7>3.0.co;2-x
Subject(s) - angiogenesis , colorectal cancer , vascular endothelial growth factor , pathology , metastasis , blood vessel , cancer , vascular endothelial growth factor a , medicine , cancer research , biology , vegf receptors
We previously demonstrated an association between vascular endothelial growth factor (VEGF), vessel counts and metastasis in human colon cancer specimens. Mutant p53 has been implicated in the regulation of angiogenesis. Immuno‐histochemical detection of p53 protein has been associated with p53 gene mutations. We sought to determine a correlation between p53 protein detection ( i.e., mutant p53), VEGF expression and vessel counts in human colon cancer. Surgical specimens from 93 patients with colon cancer were stained immuno‐histochemically for p53, VEGF and factor VIII. Vessel counts were greater in metastatic tumors than in non‐metastatic tumors and adenomas, and greater in non‐metastatic tumors than in adenomas. Vessel counts were highest in tumors with the highest VEGF expression. Vessel counts and VEGF expression were greater in p53‐positive tumors than in p53‐negative tumors. p53 expression correlated with both VEGF expression and vessel count. The association of p53 expression with VEGF and vessel count suggests that the poor prognosis associated with p53 mutations may be due, in part, to the role of mutant p53 in promoting angiogenesis. Int. J. Cancer ( Pred. Oncol. ) 79:34–38, 1998. © 1998 Wiley‐Liss, Inc.