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Dose‐dependent regression of HeLa cell‐derived tumours in SCID mice after parvovirus H‐1 infection
Author(s) -
Faisst Steffen,
Guittard Dominique,
Benner Axel,
Cesbron Jean Y.,
Schlehofer Jörg R.,
Rommelaere Jean,
Dupressoir Thierry
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980209)75:4<584::aid-ijc15>3.0.co;2-9
Subject(s) - parvovirus , parvoviridae , hela , biology , virus , virology , minute virus of mice , ratón , carcinoma , cancer research , cell , immunology , pathology , medicine , genetics
Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical‐ or virus‐induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H‐1 to inhibit therapeutically the growth of established tumours originating from human carcinoma cells implanted in recipient mice. To this end, quickly growing s.c. carcinomas were established by injection of human cervical carcinoma cells (HeLa) into immunodeficient (SCID) mice. Tumour‐bearing mice subsequently were inoculated with H‐1 at various multiplicities of infection. H‐1 virus infection led to regression of tumours, the onset and efficiency of which were dose‐dependent. Int. J. Cancer 75:584–589, 1998. © 1998 Wiley‐Liss, Inc.