Premium
Loss of heterozygosity at loci from chromosome arm 22Q in human sporadic breast carcinomas
Author(s) -
Allione Florence,
Eisinger François,
Parc Patricia,
Noguchi Tetsuro,
Sobol Hagay,
Birnbaum Daniel
Publication year - 1998
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19980119)75:2<181::aid-ijc3>3.0.co;2-q
Subject(s) - loss of heterozygosity , biology , carcinogenesis , chromosome , microsatellite , deletion mapping , breast cancer , tumor suppressor gene , genetics , long arm , cancer research , gene , cancer , allele
Forty‐four breast carcinomas were studied for loss of heterozygosity (LOH) at 25 microsatellite markers distributed almost evenly along chromosome arm 22q. LOH at at least one marker were observed in 66% tumors, while 6 regions of consistent LOH were identified. The size of each region ranged between 3 and 6 cM, and the distance between each region was estimated to be 8 to 12 cM. Even if not all these regions contain a bona fide tumor‐suppressor gene, it is possible that several loci from chromosome arm 22q may be involved in breast carcinogenesis. Int. J. Cancer 75:181–186, 1998. © 1998 Wiley‐Liss, Inc.