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Cell proliferation, cell death and angiogenesis in early and advanced gastric cancer of intestinal type
Author(s) -
Vindigni Carla,
Miracco Clelia,
Spina Donatella,
Presenti Loretta,
Gallorini Marcella,
Vatti Rosella,
De Stefano Alfonso,
Roviello Franco,
Pinto Enrico,
Filipe Maria I.,
Tosi Piero
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19971219)74:6<637::aid-ijc14>3.0.co;2-2
Subject(s) - mitotic index , grading (engineering) , angiogenesis , medicine , neovascularization , cancer , lymph node , proliferation index , mitosis , pathology , cancer research , apoptosis , oncology , biology , immunohistochemistry , ecology , biochemistry , microbiology and biotechnology
Mitotic (MI) and apoptotic index (AI), the sum of the 2, i.e., the turnover index (TI), tumor neovascularization (NV) and p53 expression, as well as tumor grading and node status, are evaluated in early and advanced gastric‐cancer cases. T 1 cases show significantly less frequent lymph‐node invasion and lower tumor grade, and, taken together, have significantly lower MI, AI and TI and higher values of NV than the T 2–3 cases. However, correlation of the variables shows that the above‐mentioned discrimination is due to a minority of T 1 cases (11 out of 33), while the majority of them are allocated in the same 95% ellipse of tolerance of the T 2–3 cases. Int. J. Cancer 74:637–641, 1997.© 1997 Wiley‐Liss, Inc.