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Characterization of C57BL/6 plasmacytomas lacking a c‐ myc translocation
Author(s) -
Pumphrey Janet G.,
Hausner Petr,
Rudikoff Stuart
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970904)72:5<892::aid-ijc29>3.0.co;2-9
Subject(s) - chromosomal translocation , plasmacytoma , biology , multiple myeloma , cancer research , genetics , immunology , gene
BALB/c peritoneal plasmacytomas induced by a variety of agents are invariably associated with a c‐ myc translocation. In contrast, naturally arising bone marrow plasma cell tumors in C57BL/KaLwRij mice lack this translocation. This difference has led to the suggestion that these are 2 fundamentally different plasma cell diseases. Herein, we have analyzed 2 rare C57BL/6 peritoneal plasmacytomas in terms of characteristics associated with the bone marrow–derived lines. Like the bone marrow lines, these peritoneal plasmacytomas do not exhibit c‐ myc translocations, indicating that c‐ myc translocation is not an obligatory event in the development of all murine extramedullary plasmacytomas. However, myc is dysregulated at the mRNA level, indicating that myc over‐expression may be fundamental to most plasma cell diseases but that dysregulation can occur by alternative mechanisms possibly reflecting different genetic backgrounds. Int. J. Cancer 72:892–897, 1997. Published 1997 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.