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Cytogenetic findings in metastases from colorectal cancer
Author(s) -
Bardi Georgia,
Parada Luis Antonio,
Bomme Lilian,
Pandis Nikos,
Johansson Bertil,
Willén Roger,
Fenger Claus,
Kronborg Ole,
Mitelman Felix,
Heim Sverre
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970807)72:4<604::aid-ijc9>3.0.co;2-u
Subject(s) - colorectal cancer , primary tumor , lymph node , pathology , cytogenetics , cancer , medicine , somatic evolution in cancer , lymph , metastasis , biology , oncology , chromosome , gene , genetics
Eighteen tumor samples from 11 patients with metastatic colorectal cancer were cytogenetically analyzed after short‐term culturing. Of the 13 metastases examined, 11 were from lymph nodes, 1 from the peritoneum and 1 from the lung. In 5 of the 11 patients, matched samples from the primary tumor and lymph node metastases were analyzed. Cytogenetic similarities between the primary and secondary lesions were found in all 5 cases, indicating that many of the chromosomal aberrations presumably occurred before disease spreading took place. Compared with the primaries, the metastases appeared to exhibit decreased clonal heterogeneity but, concurrently, an increase in the karyotypic complexity of individual clones. Among the aberrations recurrently found in metastatic lesions were del(1)(p34), i(17)(q10), −18, −Y, −21, +7 and +20, all of which have been seen repeatedly in previous series of primary colorectal carcinomas, and del(10)(q22) and add(16)(p13), which so far have not been associated with primary tumors and which may play a particular pathogenetic role in the metastatic process. Int. J. Cancer 72:604–607, 1997. © 1997 Wiley‐Liss, Inc.