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Lack of phospholipase A 2 mutations in neuroblastoma, melanoma and colon‐cancer cell lines
Author(s) -
Haluska Frank G.,
Thiele Carol,
Goldstein Alisa,
Tsao Hensin,
Benoit Eric P.,
Housman David
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970717)72:2<337::aid-ijc22>3.0.co;2-b
Subject(s) - neuroblastoma , biology , cancer research , tumor suppressor gene , melanoma , colorectal cancer , cancer , pathogenesis , cell culture , immunology , genetics , carcinogenesis
A candidate murine tumor‐suppressor gene, Mom 1, has been identified as the secretory phospholipase A2 (GDB nomenclature: PLA2G2A ) gene. Evidence suggests that PLA2G2A functions as a tumor‐suppressor because mice lacking PLA2G2A expression demonstrate increased colonic polyposis. The human homologue of PLA2G2A has been mapped to chromosome 1p36, a region frequently implicated in the pathogenesis of neuroblastoma, colon cancer and melanoma. We identified 2 alterations in the PLA2G2A gene in a single neuroblastoma cell line out of 20 examined; however, we found no mutations in 24 melanoma cell lines, 12 lymphoblastoid cell lines from patients having chromosome 1‐linked familial melanoma and 10 colon cancer cell lines. Secretory phospholipase A2 is unlikely to play a significant role in the pathogenesis of these tumors. Int. J. Cancer 72:337–339, 1997. © 1997 Wiley‐Liss, Inc.