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SV‐IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells
Author(s) -
Peluso Gianfranco,
Marchese Magda,
Furgi Annita,
Ranieri Marilena,
Russo Spena Silvana,
Ravagnan Giampietro,
Fuggetta Maria Pia,
Porta Raffaele,
Metafora Vittoria,
Metafora Salvatore
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970717)72:2<321::aid-ijc20>3.0.co;2-h
Subject(s) - lymphoblast , raji cell , peripheral blood mononuclear cell , lymphocyte , cytotoxic t cell , epithelium , biology , immunology , peripheral blood , cell culture , microbiology and biotechnology , antibody , in vitro , biochemistry , genetics
The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV‐IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell‐to‐cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV‐IV‐induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells. Int. J. Cancer 72:321–328, 1997. © 1997 Wiley‐Liss, Inc.