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Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma
Author(s) -
Maeda Kiyoshi,
Chung YongSuk,
Kang SoonMyoung,
Ogawa Masafumi,
Onoda Naoyoshi,
Nakata Bunzo,
Nishiguchi Yukio,
Ikehara Teruyuki,
Okuno Masahiro,
Sowa Michio
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970620)74:3<310::aid-ijc13>3.0.co;2-f
Subject(s) - cyclin d1 , colorectal cancer , adenocarcinoma , cancer research , carcinogenesis , cell cycle , immunohistochemistry , medicine , cyclin , cancer , disease , oncology , biology
Multiple genetic changes occur during the evolution of normal cells into cancer cells. It has been reported that both cyclin D1 and p53 genes play major roles in oncogenesis and/or cell cycle control in various cancers. In this study, we examined the overexpression of cyclin D1 and p53 by the immunohistochemical method and investigated the correlation between expression of these antigen and prognosis in patients with colorectal adenocarcinoma. Disease‐free survival was significantly lower in the patients with cyclin D1‐strongly positive tumors than in those with cyclin D1‐negative tumors. Similarly, disease‐free survival of the patients with p53‐strongly positive tumors was significantly lower than that of those with p53‐negative tumors. Moreover, multivariate analysis indicated that both cyclin D1 and p53 overexpression are independent prognostic factors in patients with colorectal adenocarcinoma. In conclusion, both cyclin D1 and p53 overexpression may be useful predictors of disease recurrence in patients with colorectal adenocarcinoma. Int. J. Cancer 74:310‐315, 1997. © 1997 Wiley‐Liss, Inc.