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Effect of angiogenesis inhibitor TNP‐470 on the progression of human gastric cancer xenotransplanted into nude mice
Author(s) -
Kanai Toshikazu,
Konno Hiroyuki,
Tanaka Tatsuo,
Matsumoto Keigo,
Baba Megumi,
Nakamura and Satoshi,
Baba Shozo
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970529)71:5<838::aid-ijc23>3.0.co;2-2
Subject(s) - angiogenesis , metastasis , cancer , medicine , transplantation , angiogenesis inhibitor , neovascularization , cancer research , pathology , primary tumor
The effect of an angiogenesis inhibitor, TNP‐470, on primary tumor growth, liver metastasis and peritoneal dissemination of gastric cancer was investigated by means of an orthotopic xenotransplanted model of 2 human gastric cancers, MT‐2 and MT‐5. TNP‐470 showed a significant inhibitory effect on the growth of primary tumors after orthotopic transplantation of both xenografts when given at a dose of 30 mg/kg on alternate days from day 7 after transplantation (early treatment). However, growth of the MT‐2 primary tumor was not inhibited by administration from day 14 after transplantation (late treatment). Liver metastasis was prevented significantly by early treatment of TNP‐470. In particular, early treatment of MT‐2 completely inhibited the development of macroscopic foci in the liver and was significantly more effective than late treatment. Peritoneal dissemination also was inhibited. Thus, TNP‐470 was revealed to have strong inhibitory activity not only on primary tumors and liver metastases but also against peritoneal dissemination. These results suggest that this agent may provide a new approach to the treatment of gastric cancer. Int. J. Cancer 71: 838‐841, 1997. © 1997 Wiley‐Liss Inc.