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Chromosome 16 in primary prostate cancer: A microsatellite analysis
Author(s) -
Osman Iman,
Scher Howard,
Dalbagni Guido,
Reuter Victor,
Zhang ZuoFeng,
CordonCardo Carlos
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970516)71:4<580::aid-ijc12>3.0.co;2-g
Subject(s) - microsatellite , biology , prostate cancer , chromosome , prostate , cancer , genetics , population , gene , cancer research , medicine , allele , environmental health
Cytogenetic and molecular genetic analyses of prostate cancer specimens have revealed nonrandom chromosomal deletions, affecting chromosomes 7q, 8p, 10q and 16q. Based on these data, we designed this study to further characterize the altered region(s) on chromosome 16 by evaluating 16 microsattelite markers on a population composed of 32 paired normal and primary prostatic tumor samples. The 16 microsatellites selected mapped to II distinct loci on 16q and 5 loci on 16p. No alterations were identified affecting 16p. However, 16 of 31 (51%) informative cases showed molecular alterations in at least one of the loci analyzed on 16q, consisting of 18 deletions and 11 bandshifts. Moreover, most of the deletions clustered at 6 microsatellite loci, mapping to the 16q22.1‐23.1 region. Our results suggest that microsatellite alterations on the long arm of chromosome 16 are frequent events in prostate cancer, and that the 16q22.1‐23.1 region might harbor a tumor suppressor gene involved in prostate cancer. Int. J. Cancer 71:580‐584, 1997. © 1997 Wiley‐Liss, Inc.