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Reactive oxygen species as mediators of the transformed phenotype
Author(s) -
Jürgensmeier Juliane M.,
Panse Jens,
Schäfer Reinhold,
Bauer Georg
Publication year - 1997
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19970304)70:5<587::aid-ijc16>3.0.co;2-a
Subject(s) - reactive oxygen species , phenotype , stimulation , microbiology and biotechnology , oxygen , phenotypic switching , chemistry , biology , biochemistry , cancer research , endocrinology , gene , organic chemistry
Reactive oxygen species (ROS) are known to be involved in different pro‐ and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage‐independent growth of transformed murine fibroblasts is inhibited by antioxidants and radical scavengers in a concentration‐dependent and reversible manner. These agents also reduce TGF‐β‐dependent stimulation of colony formation in soft agar, pointing to their specific interference with TGF‐β‐triggered signal chains involved in the maintenance of the transformed state. Int. J. Cancer 70:587–589 © 1997 Wiley‐Liss Inc.